Investigational Immunotherapy Trials for Hematological Cancers

The Keynote hematology clinical trials are studying an investigational drug, pembrolizumab, to see if it is safe and if it helps slow down or stop the growth of hematological cancers. These types of cancers (also known as blood cancers) begin in blood-forming tissues like the bone marrow or in the cells of the immune system. They include:

  • Multiple Myeloma 
  • Classical Hodgkin Lymphoma
  • Chronic Lymphocytic Leukemia
  • Primary Mediastinal and Diffuse Large B-cell Lymphoma
  • Richter Syndrome

Pembrolizumab is an investigational immunotherapy that may help the body’s immune system attack cancer cells. When a cancer cell binds to an immune cell, the immune cell can’t do its job. These trials want to see if pembrolizumab can block cancer cells from binding with immune cells to help allow the immune cells to work properly.

Participating in a clinical trial is an important decision. Anyone participating in a trial should know as much as possible about what is being studied, what risks are involved and what potential benefits may be gained before deciding to enroll. If you are interested in participating in a clinical trial, please talk to your doctor first.

You can also call our clinical trial information center at 1-888-577-8839 to learn more.

Active Clinical Trials

Trial Description Keynote Trial Condition Phase Status
keynote study logo Study of Pembrolizumab Combination Treatments in Hematologic Malignancies 155
  • Multiple Myeloma
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Lymphoma, Large B-Cell, Diffuse
  • Lymphoma, Non-Hodgkin
  • Lymphoma, Follicular
Phase 1 Recruiting
keynote study logo Study of Pembrolizumab vs. Brentuximab Vedotin in Participants With Relapsed or Refractory Classical Hodgkin Lymphoma 204 Hodgkin Lymphoma Phase 3 Recruiting
keynote study logo Study of Pembrolizumab in Participants With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma or Relapsed or Refractory Richter Syndrome 170
  • Mediastinal Large B-cell Lymphoma
  • Richter Syndrome
Phase 2 Active, not recruiting
keynote study logo Study of Pomalidomide and Low Dose Dexamethasone With or Without Pembrolizumab in Refractory or Relapsed and Refractory Multiple Myeloma 183 Multiple Myeloma Phase 3 Suspended
keynote study logo Study of Lenalidomide and Dexamethasone With or Without Pembrolizumab in Participants With Newly Diagnosed Treatment Naive Multiple Myeloma 185 Multiple Myeloma Phase 3 Suspended
keynote study logo A Trial of Pembrolizumab in Participants With Blood Cancers 013
  • Myelodysplastic Syndrome
  • Multiple Myeloma
  • Hodgkin Lymphoma
  • Non-Hodgkin Lymphoma
  • Diffuse Large B-Cell Lymphoma
  • Follicular Lymphoma
  • Primary Mediastinal B-Cell Lymphoma
Phase 1 Active, not recruiting
keynote study logo A Study of Pembrolizumab in Combination With Standard of Care Treatments in Participants With Multiple Myeloma 023 Multiple Myeloma Phase 1 Recruiting
keynote study logo Study of Pembrolizumab in Participants With Relapsed or Refractory Classical Hodgkin Lymphoma 087 Hodgkin Lymphoma Phase 2 Active, not recruiting

Clinical Trials: Important Information to Consider

There is a lot to consider when deciding whether to participate in a clinical study. Any clinical study includes risks, which the study doctor will review with you. Make sure you understand the risks before participating.